IMP3 is an mRNA-binding protein shown to be over-expressed in PDAC and various other malignancies including cervical [8], endometrial [12,13], bladder [14], lung [15], renal cell [16,17] and breast carcinomas [18,19] as well as glioblastoma [9] and malignant melanoma [20]. The gene discussed is IMP3; the disease is melanoma.