The expression of IMP3 protein in pancreatic cancer cell lines derived from primary tumours (PANC-1 and MiaPaCa-2) and distant metastatic (HPAF-II, Hs766T, L3.6pl) sites is shown in Figure 1A. IMP3 was highly expressed in human pancreatic cancer cell lines and interestingly, in KRASV12-transformed human pancreatic ductal epithelial cells as well. This evidence concerns the gene IMP3 and familial pancreatic carcinoma.