EGFR and central nervous system cancer: Herein, we showed that Nimotuzumab was effective in Asian patient-derived human glioma cell lines which expressed wild-type EGFR (Figure 2A-D), and Caucasian patient-derived human glioma cell lines expressing either wild-type EGFR (Figure 3B) or mutant EGFRvIII (Figure 3C), indicating that the effect of Nimotuzumab was indeed independent of the endogenous EGFR mutation status [22].