For the analysis of the immunogenicity and efficacy of AFFITOPE® vaccines in a MSA model, MBP-α-syn tg mice were immunized six times at monthly intervals applying conjugate vaccines containing either the AFFITOPE® AFF 1 (mimicking the C-terminus of α-syn) or the original C-terminal α-syn peptide (α-syn 110–130) coupled to Keyhole limpet hemocyanin (KLH) as carrier and using alhydrogel as adjuvant. This evidence concerns the gene MBP and multiple system atrophy.