Although the tensile stress on disc cells have been studied in vitro, some cytokines including TNF-α [13], interleukin-1(IL-1) [14], nitric oxide (NO) [15], interferon (IFN)-γ, and interleukin-4 (IL-4) [16] have been reported to promote the deterioration of intervertebral disc degeneration. This evidence concerns the gene IL4 and Intervertebral disk degeneration.