The response of cultured DC from lupus mice and normal mice to MVs from 4-NQO-treated 32Dcl3 cells revealed induction of CD40 that was significantly higher in MRL/lpr DC using 50 μg/ml MVs, while it was comparable with normal mice using 100 μg/ml MVs or LPS (Figure 2A and B). The gene discussed is CD40; the disease is systemic lupus erythematosus.