In addition, cyproheptadine-induced activation of p38 MAPK signaling and the resulting induction of HBP1 and p16INK4A expression may trigger premature senescence [20], which has been suggested to play a role in tumor suppression by reducing the replicative potential of cells [62] and is frequently detected in tumors obtained from patients who had undergone genotoxic chemotherapy [63]. This evidence concerns the gene CDKN2A and neoplasm.