CCND1 and Miyoshi myopathy: Furthermore, qPCR analyses showed a 2.5- to 4-fold lower expression of cyclin E1 and a 5- to 6-fold overexpression of cyclin D1 in ND-MM-BMMSCs and R-MM-BMMSCs compared to HD-BMMSCs (p < 0.05; Figure 1C).