In the current study, we tested this hypothesis, investigating the impact of concurrent inhibition of IGF-IRs and epidermal growth factor receptors (EGFR/Her-2) by NVP-AEW541 and lapatinib tyrosine kinase inhibitors, respectively, on pancreatic cancer cell lines and particularly on PCSCs. This evidence concerns the gene ERBB2 and familial pancreatic carcinoma.