KRAS and non-small cell lung carcinoma: Yet another phase II study with combination therapy in previously-treated NSCLC patients, this one with erlotinib plus tivantinib (ARQ 197) (MET-TKI) versus just erlotinib alone in previously-treated NSCLC patients showed that the median PFS was longer in the erlotinib plus tivantinib group than in the erlotinib alone group, particularly among patients with KRAS mutations, although this study did not meet its primary end point [21].