(C,D) Kaplan-Meier analyses for CSS and RFS of ccRCC patients according to CSF-1 expression in patients of TNM III + IV (C) CSS (left, training cohort, n = 61, P = 0.017; right, validation cohort, n = 16, P = 0.007) (D) RFS (left, training cohort, n = 52, P = 0.032; right, validation cohort, n = 8, P = 0.027). The gene discussed is CSF1; the disease is nonpapillary renal cell carcinoma.