In our research, high serum levels of fibulin-4, CA-125 and CA19-9 were all found in ovarian carcinoma when compared with healthy control and benign ovarian tumor, and high fibulin-4, CA-125 and CA19-9 levels were associated with low differentiation, advanced stage and positive lymph node status in ovarian carcinomas. The gene discussed is EFEMP2; the disease is ovarian benign neoplasm.