It is noteworthy that deletion of the Ro60 orthologue in mice results in selective development of a lupus-like autoimmunity syndrome including increased photosensitivity, membranoproliferative glomerulonephritis and production of autoantibodies suggesting that one role of Ro60 may be to prevent certain forms of autoimmunity [40]. The gene discussed is RO60; the disease is membranoproliferative glomerulonephritis.