FN1 and neoplasm: Although, the nuclear accumulation of GFP-H3-Op-T-NLS was significantly elevated compared to GFP-H3 alone, the increase was comparable across the MCF10A, MCF10AT and MCF10CA1h cell lines, with no significant difference in Fn/c observed (Figure 2B, C), confirming that the tumour-cell selective activity of these novel histones is not a general feature of NLSs but a unique property of the Apoptin tNTS.