Recently, four additional clinical reports were published on patients with germline PIGA mutations depicting a wide spectrum of phenotypes and clinical diagnoses [7,16-18], including West syndrome [18], Multiple congenital anomalies-hypotonia-seizures syndrome 2 (MCAHS2) [17,18] and Ferro-Cerebro-Cutaneous syndrome (FCCS) [16]. The gene discussed is PIGA; the disease is ferro-cerebro-cutaneous syndrome.