LPL release from endothelial cells in response to heparin stimulation requires the activity of GPIHBP1 (GPI-anchored high-density lipoprotein binding protein 1) and primary genetic defects in this GPI-anchored protein lead to hypertriglyceridemia and non-detectable serum lipoprotein lipase [33]. This evidence concerns the gene GPIHBP1 and hypertriglyceridemia.