For overall 249 breast tumor samples (p = 0.0007), 211 of ER+ subgroups (p = 0.005), 34 of ER- subgroups (p = 0.03), 20 of ER-LN- subgroups (p = 0.007) all showed an inverse correlation of FEN1 gene expression with DFS (Figure 6A). Here, ESR1 is linked to breast neoplasm.