Regardless, a decreased functionality of both PB and BM iNKT-cells is seen in MM patients, with the progression of the disease correlating with a loss of IFN-γ production by iNKT-cells.71 Studies have also shown the loss of CD1d expression by MM cells upon progression of the disease, suggesting a mechanism by which MM cells evade targeting by iNKT-cells.70, 71, 73, 74 Tumor cells themselves may also both express and shed glycolipids that contribute to NKT-cell dysfunction in MM.71 This evidence concerns the gene IFNG and Miyoshi myopathy.