BCL2 and cancer: In general there are many lines of evidence demonstrating that the dysregulation of Bcl-2 family members, −especially the overexpression of anti-apoptotic Bcl-2 proteins in various malignancies (including those of the genitourinary tract)-, is crucial for not only the failure of standard therapy with the promotion of chemoresistance, but also correlates with progression of cancer, disease recurrence and disease specific mortality [11,43,44,52-57].