Indeed, treatment with an activator of CD8+ T cells, Ipilimumab (anti-CTLA-4), together with an inhibitor of VEGF signaling (Bevacizumab) causes perivascular CD8+ cell accumulation [40], thus confirming the relevance of the vasculature for tumor-infiltration of cytotoxic T cells. The gene discussed is CTLA4; the disease is neoplasm.