Of the angiogenic factors VEGF, Angiopoietin-2, PECAM-1, Follistatin, Leptin, G-CSF, HGF, PDGF-BB and IL-8, two angiogenic factors (HGF and Follistatin) are associated with esophageal cancer patients’ prognosis in posttherapeutic tumor tissue. This evidence concerns the gene PECAM1 and esophageal cancer.