Tumor size >2.0 cm (p = 0.001), serum CEA >5.0 mg/dL (p < 0.001), high urinary DiAcSpm (p = 0.002), and TDR > 0.75 (p < 0.001) were more frequently observed in patients with invasive tumors than in those with non-invasive tumors. This evidence concerns the gene CEACAM5 and neoplasm.