FLT3LG and acute myeloid leukemia: Of note, the cell-signaling based classifier developed in a pediatric AML population referenced above [9] included as input three signaling nodes measuring functional apoptosis, PI3 kinase, and proliferation pathways (i.e. etoposide induced c-PARP, FLT3L-induced p-S6, and Thapsigargin induced p-Erk).