The children of GCA with the combined genotype with ITGA5-1160/ITGB1-1949/ITGB1 + 31804 as T/A/C carriers and COX-2-1195/IL-10-592 as G-carrier/AA had a 5.25-fold higher risk to have SPEM (P = 0.016) (Table 3). This evidence concerns the gene ITGB1 and temporal arteritis.