The combined genotype as ITGA5-1160/ITGB1-1949/ITGB1 + 31804 as T/A/C carriers and COX-2-1195/IL-10-592 as G-carrier/AA significantly predisposed to the precancerous lesions such as SPEM after H. pylori infection in children of GCA. Here, ITGA5 is linked to temporal arteritis.