The combined genotype such as ITGA5-1160/ITGB1-1949/ITGB1 + 31804 as T/A/C carriers and COX-2-1195/IL-10-592 as G-carrier/AA, or even more specifically combined with RUNX3 + 492/TFF2-308, may thus serve as a host factor to identify the risk group of gastric cancer for an early H. pylori eradication. Here, PTGS2 is linked to gastric cancer.