When taking more SNPs with COX-2-1195/IL-10-592 and RUNX3/TFF2 into consideration, the allele frequencies of the complicated model (ITGA5-1160/ITGB1-1949/ITGB1 + 31804 as T/A/C carriers, COX-2-1195/IL-10-592 as G-carrier/AA, and RUNX3/TFF2 as A-carrier/cm3) remained higher in children of GCA than in DU (17% vs. 6%, P = 0.003). The gene discussed is RUNX3; the disease is temporal arteritis.