Furthermore, children of the GCA index patients carrying the combination sets of ITGA5-1160/ITGB1-1949/ITGB1 + 31804/COX-2-1195/IL-10-592 as T-carrier/A-carrier/C-carrier/G-carriers/AA also had a higher prevalence of the same combination SNPs than children of GCA index patients not carrying such combinations of SNPs (43% vs. 16%; P = 0.003; OR 3.9; 95% CI: 1.6-9.6). The gene discussed is PTGS2; the disease is temporal arteritis.