With regards to no significant difference of allele frequencies of SNPs in RUNX3 and TFF2 genes between the children of GCA with low risk DU, the host-bacterial interaction regulated by integrin α5β1 and the chronic inflammation regulated by IL-10 and COX-2 may be prior to the regulation of RUNX3 and TFF2 in the gastric carcinogenesis process. This evidence concerns the gene RUNX3 and temporal arteritis.