Circulating granulocyte neutrophil cells count, at the numerator, were been shown to contain and secrete the majority of cytokines, such as vascular endothelial growth factor (VEGF), interleukin-18 (IL-18) and matrix metalloproteinases (MMM), that create the optimal environment for tumor growth, progression and metastasis [39-41]. The gene discussed is IL18; the disease is neoplasm.