CXCR4 and neoplasm: (3) The expression of tumor-promoting factors (CXCR4, MMP-9, NF-κB), which are involved with CRC proliferation, metastasis and tumor invasion were significantly increased in the alginate proliferating- and invasive cells compared to the adhered cells, however HCT116R overexpressed more proteins in comparison to the HCT116 cells.