Next, we characterized TF-TF, miRNA-TF, and distTF-TF logic operations by integrating ENCODE and TCGA AML datasets using Loregic, where distTF represents a TF regulating its target through a distal regulatory region such as an enhancer, whereas the canonical TF regulation is assumed to occur at the proximal promoter (Materials and Methods, and S2–4 Tables). The gene discussed is TF; the disease is acute myeloid leukemia.