SREBF1 and diabetic kidney disease: In the current study, renal expression of SREBP-1c mRNA showed a one fold increase in hamsters in the D-HFHC group, which possibly resulted in lipid accumulation in the kidney by TGF-β inhibiting glomerular endothelial, epithelial, and mesangial proliferation and mediating the hypertrophic and fibrotic/sclerotic manifestations of diabetic nephropathy.