Surprisingly, the latter finding is potentially inconsistent with the notion that among postmenopausal women, obesity is generally associated with higher plasma levels of estradiol from adipose tissue [31] and greater risk of ER+ (primarily Luminal A) breast cancer [32,33], and suggests that even if higher circulating estradiol is available in postmenopausal women, the tumor itself may be less responsive to endogenous estrogen depending on level of obesity. This evidence concerns the gene ESR1 and neoplasm.