BDNF and brain infarction: In summary, statin therapy after a cerebral infarct blocks the spread of damage and helps to restore brain morphology and functionality, at least based on the induction of trophic factors such as BDNF and of cell adhesion proteins that generate a platform for synaptic proteins, such as PSD-95, and NMDA receptors to settle and generate synaptic connectivity, neurotransmission, and cognitive and motor function recovery.