A recent study about Alzheimer’s disease found that the antisense transcript of the Alzheimer-associated b-secretase-1 (BACE), known as BACEAS, increases BACE mRNA stability [43], most likely by masking the binding sites for miR-485-5p [83], which suggested that lncRNAs could interfere with miRNA-mediated mRNA destabilization. This evidence concerns the gene BACE1 and early-onset autosomal dominant Alzheimer disease.