Testing all ESCC cell lines for the relative contribution of HGF/MET and FGF/FGFR in a similar experiment, demonstrates that four cell lines (KYSE220, TTN, TE-6, and TE-15) are dependent on HGF/MET, while eight cell lines (KYSE30, KYSE50, TT, TE-6, TE-9, TE-11, TE-14, and TE-15) are dependent on FGF/FGFR. The gene discussed is HGF; the disease is esophageal squamous cell carcinoma.