HMGCR and hyperlipidemia: Triton WR-1339 is a non-ionic surfactant, which elevates the plasma lipids on administration, causes changes in circulatory lipoproteins, suppresses lipoprotein lipase (LPL) activity, hinders the uptake of circulating lipids by extra hepatic tissues, and increases the HMG-CoA reductase activity resulting in increased blood lipid concentrations, hence hyperlipidemia.