To further assess the frequency of BRCA1 and BRCA2 mutations, a subgroup of 116 women with ovarian cancer ascertained within a three-year window were investigated for mutations using a broader panel of 19 mutations, which included the 13 additional variants previously reported in French Canadian cancer families and thus accounting for all BRCA1/BRCA2 mutations reported in French Canadians of Quebec. This evidence concerns the gene BRCA1 and cancer.