BRCA1 and Hereditary breast and ovarian cancer syndrome: We have shown that five specific mutations (BRCA1: C4446T and 2953delGTAinsC and; BRCA2: 8765delAG, G6085T, 3398del5) account for the majority (85%) of all mutation-positive breast cancer and breast-ovarian cancer families, where index mutation carriers self-reported four grandparents of French Canadian descent [27] and haplotype analysis of these variants showed that they were likely due to common ancestors [25,26,29,33].