However, only six of the 19 BRCA1 (C4446T, 2953delGTAinsC, and 3875del4) and BRCA2 (8765delAG, 3398del5, and G6085T) mutations screened in our study were evaluated in this independent report and thus it remains to be determined if the carrier frequency in ovarian cancer patients would exceed that found in women with breast cancer ascertained from the same population if similar genetic testing strategies are used. The gene discussed is BRCA1; the disease is breast carcinoma.