In a targeted mutation analysis of BRCA1 (C4446T, 2953delGTAinsC, 3768insA) and BRCA2 (2816insA, 8765delAG, G6085T, 6503delTT) mutations found to recur at least twice in French Canadians, we reported a mutation carrier frequency of 8% in 99 women with epithelial ovarian cancer not selected for histological subtype or family history of cancer [36]. The gene discussed is BRCA2; the disease is cancer.