Therefore to assess the contribution of recurring BRCA1/BRCA2 mutations in ovarian cancer cases from French Canadians, genomic DNA from 429 ovarian carcinomas and 10 fallopian tube or primary peritoneal carcinomas was screened for the presence of the two BRCA1 (C4446T, 2953delGTAinsC) and four BRCA2 (8765delAG, G6085T, 3398del5, E3002K) mutations using established PCR-based assays (Table 2). This evidence concerns the gene BRCA1 and ovarian carcinoma.