Notable is that although our screen was targeted to 19 specific variants, our estimated carrier frequency of 16.4% is similar to the overall BRCA1 and BRCA2 mutation carrier frequency of 13-15% that has been reported for women with ovarian cancers not selected for family history or from demographically defined populations, where more comprehensive whole gene analyses were conducted [12,14-16,18]. This evidence concerns the gene BRCA1 and ovarian cancer.