Recent studies have demonstrated that the anti-fibrogenic strategies, such as development of a more biocompatible PD solution, treatment of TGF-β-inhibiting proteoglycan and inhibition of the renin-angiotensin system, have the potential to attenuate or prevent the onset of peritoneal fibrosis in multiple animal models [9-12]. The gene discussed is TGFB1; the disease is Peritoneal Fibrosis.