Median urine periostin levels in healthy controls [1.15 (IQR: 0.60, 1.63) ng/mgCr] was significantly less than in patients with normoalbuminuric type 2 diabetes [3.06 (IQR: 1.12, 6.77) ng/mgCr, p<0.001], microalbuminuric type 2 diabetes [8.71 (IQR: 5.09, 19.29) ng/mgCr, p<0.001] and macroalbuminuric type 2 diabetes [13.58 (IQR: 3.99, 16.19) ng/mgCr, p<0.001] (Fig 2)(S1 Dataset). The gene discussed is POSTN; the disease is type 2 diabetes mellitus.