A model for how a hydrophobic 7-transmembrane receptor such as CXCR7 might traffic to the nucleus to modulate gene transcription is shown in Figure 9B. Future studies are warranted to test the validity of such mechanisms in prostate-cancer cells and to determine whether these are features that are restricted to neoplastic prostate epithelial cells. Here, ACKR3 is linked to Familial prostate cancer.