AR and Familial prostate cancer: In light of the finding that CXCR7 expression is required for normal AR transcriptional activity, the pre-engagement of CXCL11 or CXCL12 with CXCR7 in the context of androgen depletion likely disrupts the physical interactions between CXCR7 and AR that promote maximal AR transcriptional activity in prostate-cancer cells.