By using a stringent quality control method to exclude the analysis of potentially degraded samples, we have concluded that there is no large association between colorectal adenomas status and systemic levels of proinflammatory (TNF-α, IL-6, IL-1β) or T-cell polarizing (IL-12, IL-2, IL-10, IL-4, IL-17, IFN-γ) cytokines among a subset of participants from the IRAS Colon Study. The gene discussed is TNF; the disease is colorectal adenoma.