Increased HIF-1α levels have been found in many tumor types, accompanied by increased expression of HIF-1 target genes, including but not limited to, vascular endothelial growth factor A (VEGFA), phosphoglycerate kinase 1 (PGK1), angiopoietin-like 4 (ANGPTL4), carbonic anhydrase IX (CAIX) and hexose kinase 2 (HK2) [14]. The gene discussed is HK2; the disease is neoplasm.