Data previously reported from our cohort demonstrated significantly increased CD4+ HLADR+ levels in HIV/HCV coinfection with CHC compared to HIV/HCV coinfection with cleared HCV and HIV monoinfection, though not significantly different from HCV monoinfection, suggesting that CD4 + HLADR+ expression is driven by HCV viremia [19]. Here, CD4 is linked to cryohydrocytosis.