Compared with those with the lowest serum irisin (quartile 1 group), subjects with the highest (quartile 4 group) showed significantly decreased risk of CKD and marginally decreased risk of albuminuria, with the adjusted ORs (95% CI) of 0.572 (0.353-0.927, p = 0.023) and 0.611 (0.373-1.000, p = 0.050), respectively. This evidence concerns the gene FNDC5 and chronic kidney disease.