Overall KRAS was the most frequently mutated gene in patients with disseminated disease (Figure 1c) and KRAS codon 12 glycine to valine mutations was seen in 10 of 34 KRAS mutated tumours in patients with disseminated disease compared to 2 of 14 KRAS mutated tumours in patients with non-disseminated disease (data not shown). Here, KRAS is linked to neoplasm.