The urinary levels of HMGB1 correlated with erythrocyte sedimentation rate (ESR) (r = 0.354, p = 0.012), C-reactive protein (CRP) (r = 0.289, p = 0.042), and Birmingham Vasculitis Activity Score (BVAS) (r = 0.350, p = 0.013) (Fig 3). The gene discussed is HMGB1; the disease is vasculitis.