Using a heat shock-inducible Cre-recombinase, disease penetrance was increased to 81% [62], with a follow-up study showing that co-expression of zebrafish bcl2 in this model accelerated the initiation of T-lymphoblastic lymphoma (T-LBL) but inhibited progression to T-ALL [63], similar to mouse models [64,65]. This evidence concerns the gene BCL2 and acute lymphoblastic leukemia.