It is likely that the combined action of both integrin α3β1 and ILK accounts for the effects of Angptl3 on PAN-induced podocyte detachment, which were partially correlated with Angptl3 could affect the influence of PAN on altering the expression of integrin α3, total integrinβ1, phosphorylation of integrin β1 and ILK. This evidence concerns the gene ILK and polyarteritis nodosa.