Similarly to CGE, traditional Chinese medicine Xiao-Chai-Hu-Tang was found to restore mesangial expansion, basement membrane thickening, glomerular hypertrophy, and tubular damage in T1DM rats [30] while quinapril, the angiotensin-converting enzyme inhibitor, was also able to restore defective glomerular albumin permeability in experimental diabetic nephropathy rats [31]. This evidence concerns the gene ACE and type 1 diabetes mellitus.