SLC22A6 and Renal insufficiency: In addition, previous study suggested that Oat1 and 3 play important role in renal tubular uptake of the retention of waste products, the uremic toxins, for example, indoxyl sulfate, hippurate, indoleacetate, and 3-carboxy-4-methyl-5-propyl-2-furanpropionate, and aggravated tubular damage in renal failure [35].