Using metabolomics analysis, this evidence correlated with a decrease in urinary organic anion metabolite makers seen in patients with diabetic kidney disease including homovallinic acid and 4-OH hippurate, supporting that the transport function of Oat1 and 3 was the rate-limiting step and has contributed to the urine metabolomics that could serve as novel biomarkers for diabetes with chronic kidney disease [16]. This evidence concerns the gene SLC22A6 and chronic kidney disease.