INS and type 2 diabetes mellitus: Interestingly, the effect of insulin stimulation on the increase of PAH transport remained present in the renal slices from ND + CGE, DM + CGE and DM + metformin similarly to the slices from control, implying that 1 g/kg BW of CGE was able to improve regulatory function of rOat1 and 3 similarly to that of metformin treatment in T2DM rats.