For instance, hyperglycaemia induced the productions of AGE, PKC, and NFκB and then stimulated the activities of TGF-β in both renal tubular and mesangial cells as well as VEGF in podocytes, followed by the various extracellular matrix (ECM) syntheses including collagen types I and IV and fibronectin [5, 6]. Here, PRRT2 is linked to Hyperglycemia.