However, there are many unanswered questions at present to justify this strategy: compromising intercellular adhesions may promote metastasis in cancer, whereas dysfunctional actin-related machinery might have opposite effects by preventing cell adhesion and promoting apoptosis; fundamental roles of cell junctions most probably will require targeted approach, delivery of active substances only to the diseased location; mechanisms involving afadin in pathological AG could have altered effects. The gene discussed is AFDN; the disease is cancer.