INS and Hyperglycemia: In a rat exposure study 2,2′,3,3′,4,4′,5,5′,6,6′-decabromodiphenyl ether (BDE209) exposure was shown to induce hyperglycemia, decrease insulin, glutathione, and superoxide dismutase serum levels and increase TNFα serum levels, probably via induction of oxidative damage and was further correlated to changes in rat liver cell MHC and TNFα transcripts that possibly could be involved in T1DM development [49].