In our study, CCL2 orchestrates CCR2-expressing immunomodulatory cells including Tregs, MDSCs and TAMs in the tumor microenvironment, and generates DCregs partly in collaboration with LCN2 that is released from the CCL2-stimulated tumor cells (Kudo-Saito et al., 2013b). The gene discussed is LCN2; the disease is neoplasm.