Although it is difficult to conclude whether TNC is more beneficial or detrimental for tissue healing and reconstruction after myocardial infarction, a timely and proper degree of TNC expression might be beneficial for myocardial tissue repair, whereas prolonged overexpression of TNC might interfere with sound tissue repair and cause inappropriate reconstruction of infarcted ventricle, resulting in so-called ventricular remodeling. The gene discussed is TNC; the disease is myocardial infarction.