Indeed, it has been reported that the genetic removal of either of two different eIF2α kinases (PRKR-like endoplasmic reticulum kinase, Perk, and general control nonderepressible 2, Gcn2) restores plasticity and memory impairments in an APP/PS1 mouse model of AD [14]. This evidence concerns the gene EIF2AK3 and Alzheimer disease.