The main difference between normal tissues and tumor tissues is the increased expression of the noncanonical prosurvival signaling of these receptors in tumor cells; for instance, many tumor cells overexpress TRAIL-R3 and TRAIL-R4 (decoy receptors, DcR1 and DcR2), with truncated cytoplasmic death domains that prevent the transmission of signals following binding of ligand to receptor. Here, TNFRSF10D is linked to neoplasm.